University Hospital & Medical Center at Stony Brook GLOSSARY
Male Infertility Program
![]()
- A --
Abortion
- the premature termination of a pregnancy; may be induced or spontaneous (miscarriage)Acrosome-
the packet of enzymes in a sperm's head that allows the sperm to dissolve a hole in thecoating around the egg, which allows the sperm to penetrate and fertilize the eggAcrosome reaction
-a chemical change that enables a sperm to penetrate an eggAdhesion-
a union of adjacent organs by scar tissueAdrenal glands
-the endocrine gland on top of each kidneyAgglutination-
clumping together, as of sperm, often due to infection, inflammation, or antibodiesAndrogens-
male sex hormonesAnejaculation-
absence of ejaculationAntibody-
a protective agent produced by the body's immune system in response to a foreign substanceAntigen-
any substnace that induces the formation of an antibodyAntisperm antibodies-
antibodies that can attach to sperm and inhibit movement of sperm or fertilizationArtificia
l insemination (AI)-placement of a sperm sample inside the female reproductive tract (See also intracervical insemination, intrauterine insemination, intratubal inseminationAspiration-
suctioning of fluid, as from a follicleAsymptomatic
-without any symptomsAutoantibodies-
antibodies formed against one's own tissuesAutoimmunity-
an immune reaction against one's own tissuesAzoospermia-
absence of sperm
-- B --
Bacteria-
microscopic, single-celled organisms that can cause infections of the genital tractBiopsy-
a fragment of tissue removed for study under the microscopeBlood-testis barrier-
the barrier that separates sperm from the bloodstreamBromocryptine (Parlodel)-
a drug that reduces levels of the pituitary hormone prolactin
-- C --
Cannula-
a hollow tube used, for example, to inseminate sperm artificiallyCapacitation-
the process by which sperm become capable of fertilizing an eggCatheter-
a flexible tube used for aspirating or injecting fluidsCervix-
the lower portion of the uterus that opens into the viginaChlamydia-
a type of bacteria that is frequently transmitted sexually between partners or from an infectedmother to her newborn child; the most common sexually transmitted bacterial diseaseChromosome-
threads of DNA in a cell's nucleus that transmit hereditary informationClomiphene citrate (Clomid, Serophene)-
a fertility pill that stimulates ovulation through release of gonadotropins from the pituitary glandCongenital defect-
a birth defectContraindication-
a reason not to use a particular drug or treatmentCryptorchidism-
failure of one or both testicles to descend into the scrotumCyst-
a sac filled with fluid
-- D --
Deoxyribonucleic acid (DNA)-
the combination of amino acids in the cell's nucleus that make up the chromosomes, which transmit hereditary characteristicsDiethylstilbestrol (DES)-
a synthetic estrogen (originally prescribed to prevent miscarriage) that caused malformations of the reproductive organs in some who were exposed to the drug during fetal developmentDonor insemination-
artificial insemination with donor spermDysfunction-
abnormal function
-E-
Egg(ovum)-
the female reproductive cellEjaculate-
the sperm-containing fluid released at orgasmEjaculatory ducts
-the male ducts that contract with orgasm to cause ejaculationElectrocautery-
cauterization using electircal currentElectroejaculation-
controlled electrical stimulation to induce ejaculation in a man with damage to the nerves that control ejaculationEmbryo-
the developing baby from implantation to the second month of pregnancyEmbryologist-
a specialist in embryo developmentEmbryo transfer-
placing a laboratory-fertilized egg into the uterusEndocrine gland
-an organ that produces hormonesEpididymis-
the tightly coiled, thin-walled tube that conducts sperm from the testicles to the vas deferensEpididymitis
-inflammation of the epididymisEstradiol-
the principal estrogen produced by the ovaryEstrogens
-female sex hormones
-- F --
Fallopian tubes-
ducts that pick up the egg from the ovary; where a sperm normally meets the egg to fertilize itFetus-
the developing baby from the second month of pregnancy until birthFertilization
-union of the male gamete (sperm) with the female gamete (egg)Fluoroscope
-an imaging device that uses X-rays to view internal body structures on a screenFollicle-
a fluid-filled sac in the ovary that releases an egg at ovulationFollicle stimulating hormone (FSH)-
the pituitary hormone that stimulates follicle growth in women and sperm formation in menFructose-
produced by the seminal vesicles, the sugar that sperm use for energy
-- G --
Gamete
-a reproductive cell; the sperm in men, the egg in womenGamete Intra Fallopian Transfer (GIFT)-
combining eggs and sperm outside of the body and immediately placing them into the fallopian tubes to achieve fertilizationGene-
the unit of heredity, composed of DNA; the building block of chromosomesGland-
an organ that produces and secretes essential body fluids or substances, such as hormonesGonadotropins-
the hormones produced by the pituitary gland that control reproductive function folliclestimulating hormone (FSH) and luteinizing hormone (LH)G
onadotropin releasing hormone (GnRH)-the hormone produced and released by the hypothalamus that controls the pituitary gland's production and release of gonadotropinsGonads
-organs that produce the sex cells and sex hormones; testicles in men and ovaries in womenGranuloma
-a ball of inflamed tissue, commonly formed after vasectomy due to sperm leaking from the vasdeferens
-H-
Habitual abortion
-repeat miscarriagesHamster test
-a test of the ability of a man's sperm to penetrate a hamster egg stripped of its outer membrane, the zona pellucida, Also called Hamster Zona-Free Ovum (HZFO) Test orSperm Penetration Assay (SPA)-
a laboratory test of the ability of sperm to penetrate into a human egg; first the egg is split in half, then one half is tested against the husband's sperm and the other half against sperm from a fertile manHormone-
a substance, produced by an endocrine gland, that travels through the bloodstream to aspecific organ, where it exerts its effectHostile mucus
-cervical mucus that impedes the natural progress of sperm through the cervical canalHuman chorionic gonadotropin(hCG)-
the hormone produced early in pregnancy to keep the corpus luteum producing progesterone;may be injected to stimulate ovulation and progesterone productionHuman menopausal gonadotropins(hMG)-
see PergonalHyperandrogenism-
excessive production of androgens in women, frequently a cause of hirsutism and alsoassociated with polycystic ovarian disease (PCOD)Hyperprolactinemia-
excessive prolactin in the bloodHyperstimulation-
excessive stimulation of the ovaries that can cause them to become enlargedHypothalamus-
the endocrine gland at the center of the brain that produces gonadotropin releasing hormone-and controls pituitary functionHypothyroidism-
underactivity of the thyroid gland
-- I --
Immune system-
the body's defense against any injury or invasion by a foreign substance or organismImmunoglobulins-
a class of proteins endowed with antibody activity; antibodiesImmunosuppressive drug
-a drug that interferes with the normal immune responseImmunotherapy
-a medical treatment for an immune system disorder that involves transfusing donor whiteblood cells into a woman who has had recurrent miscarriagesImplantation-
attachment of the fertilized egg to the uterine lining, usually occurring five to seven days after ovulationImpotence-
inability of a man to achieve an erection or ejaculationInfertility
-inability of a couple to achieve a pregnancy or to carry a pregnancy to term after one year ofunprotected intercourseInflammation-
a response to some type of injury such as infection, characterized by increased blood flow,heat, redness, swelling, and painIntracytoplasmic sperm injection (ICSI)-
direct injection of a single sperm into an eggIntrauterine insemination (IUI
)-artificial insemination of sperm, which have been washed free of seminal fluid, into the uterine cavityIn utero-
while in the uterus during early developmentIn vitro fertilization (IVF)-(
literally, "in glass") fertilization outside of the body in a laboratory
-- K --
Karyotype-
a chromosome analysisKlinefelter's syndrome-
a chromosome abnormality that prevents normal male sexual development and causes irreversible infertility due to the presence of an extra female (X) chromosome
-- L --
Leydig cells
-the cells in the testicles that make testosteroneLuteinizing hormone (LH)-
the pituitary hormone that causes the testicles in men and ovaries in women to manufacture sex hormones
-- M --
Metrodin(Pure FSH)-
an injectable drug consisting of pure follicle stimulating hormone used to stimulate ovulationMicrosurgery
-reconstructive surgery performed under magnification using delicate instruments and precise techniquesMorphology
-the study of form, such as assessing the shape of sperm during semen analysisMotility
-mothion, such as the forward swimming motion of health spermMucus
-secretion from a gland that can be watery, gel-like, stretchy, sticky or dry; fertile mucus iswatery and stretchyMycoplasm-
an infectious agent that falls structurally between a virus and a bacterium
-- O --
Olig
ospermia-a low sperm countOvary-
the female gonad; produces eggs and female hormonesOvulation-
release of an egg from the ovary
-- P --
Parlodel-
see BromocryptinePatent
-open; for example, fallopian tubes should be patent after a sterilization reversal operationPenetrak-
a test of how fast sperm can travel up through cow mucusPenis-
the male organ of sexual intercoursePergonal (hMG)-
the luteinizing and follicle stimulating hormones recovered from the urine of postmenopausalwomen that is used to induce multiple ovulation in various fertility treatmentsPituitary gland-
the endocrine gland at the base of the brain that produces the gonadotropin luteinizinghormone and follicle stimulating hormone, which in turn stimulate the gonads to produce sexcells and hormonesPolyp-
a growth or tumor on an internal surface, usually benignPost-coital test (PCT)-
microscopic examination of a woman's cervical mucus at the fertile time of the cycle to determine the number and motility of sperm following intercoursePre-embryo-a fertilized egg
in the early stage of development prior to cell divisionProgesterone-
the female hormone, produced by the corpus luteum after ovulation, that prepares the uterine lining for implantation of a fertilized egg and helps maintain the pregnancyProlactin-
the pituitary hormone that in high amounts stimulates milk productionProstate gland
-the male gland encircling the urethra that produces one third of the fluid in the ejaculateProstaglandins-
a group of hormone-like chemicals that have various effects on reproductive organs; sonamed because they were first discovered in the prostate gland
-- R --
Reproductive endocrinologist-
an OB/GYN who specializes in the treatment of hormonal disorders that affect reproductive functionRetrograde ejaculation-ejaculation backwards
into the bladder instead of forward through the urethra
-- S --
Scrotum-
the sac containing the testicles, epididymis, and vas deferensSemen-
the fluid containing sperm and secretions from the testicles, prostate, and seminal vesicles thatis expelled during ejaculationSemen analysis-
laboratory examination of semen to check the quality and quantity of spermSeminal vesicles-
the paired glands at the base of the baldder that produce seminal fluid and fructoseSeminiferous tubules
-in the testicles, the network of tubes where sperm are formedSeptum-
a wall that divides a cavity in half, such as a uterine septumSertoli cells-
the cells in the testicles that provide nourshment to the early sperm cellsSexually transmitted disease (STD)-
a disease caused by an infectious agent transmitted during sexSperm-
male gamete or reproductive cellSperm bank
-a place where sperm are kept frozen in lizuid nitrogen for later use in artificial inseminationSperm count
-the number of sperm in the ejaculate (when given as the number of sperm per millileter it ismore accurately known as the sperm concentration or sperm density)Sperm penetration assay (SPA)-
see Hamster testSpermicide
-an agent that kills spermSterilization-
a surgical procedure (such as tubal ligation or vasedtomy) designed to produce infertilitySterilization reversal
-a surgical procedure used to undo a previous sterilization operation and restore fertility
-- T --
Testicle-
the male gonad; produces sperm and male sex hormonesTesticular biopsy
-the removal of a fragment of a testicle for examination under the microscopeTestosterone-
the primary male sex hormoneThyroid gland-
the endocrine gland in the front of the neck that produces thyroid hormones, which regulatethe body's metabolismTotal effective sperm count
-an estimate of the number of sperm in an ejaculate capable of fertilization; total sperm count X percent motility X percent forward progressive motility X percent normal morphologyToxin
-a poison produced by a living organism, such as by some bacteriaTumor-
an abnormal growth of tissue that can be benign or malignant (cancerous)
-- U --
Ultrasound (US)-
use of high-frequency sound waves for creating an image of internal body partsUreaplasma-
a microorganism similar to mycoplasmaUrethra-
the tube through which urine from the bladder is expelledUrologist-
a physician who specializes in the surgical treatment of disorders of the uniary tract and malereproductive tractUterus
-the womb; female reproductive organ that noursishes the fetus until birth
-- V --
Vagina-
the female organ of sexual intercourse; the birth canalVaginituis
-inflammation of the viginaVaricocele-
varicose veins in the scrotumVas deferens
-the tubes that conduct sperm and testicular fluid to the ejaculatory ductsVasectomy
-surgical sterilization of a man by interrupting both vas deferensVasectomy reversal
-microsurgical repair of a previous vasectomy for a man who wants to regain his fertilityVasogram-
an X-ray study of the vas deferensVenereal disease
-see Sexually transmitted idsesas (STD)Virus-
a microscipic infectious organism that reproduces inside living cells
-- Z --
Zona pellucida
-the protective coating surrounding the eggZygote-
an egg that has been fertilized but not yet dividedZygote Intra Fallopian transfer (ZIFT)-
in vitro fertilization with a transfer of the zygote into the fallopian tube; a combination of in vitro fertilization and gamete intrafallopian transfer