School of Medicine - HBC 531
Molecules Genes and Cells
Fall - 2003
Sanford Simon, Ph. D. and Nisson Schechter, Ph.D.
Directory of Files
The following list describes a set of ".pdf" files, written in Adobe Acrobat, which contain important and useful materials for this course. In order to read these files, it will be necessary to load the Adobe Acrobat Reader onto your computer if you have not already done so. The Adobe Acrobat Reader is available for download gratis from:
http://www.adobe.com/proindex/acrobat/readstep.html
and will be useful for reading many additional files which will be generated by other courses.
Instructions for using the Acrobat Reader are included with the program. Acrobat Reader is not
capable of editing the files, but other software is available for this purpose if you wish to put
your own notes onto any of the pages for your own use.
● 1. The course schedule, reading list, and course policies.
● 1a. Room assignments for TA-led small group sessions.
● 2a. The PowerPoint file for the lectures on primary structure of proteins.
● 2b. The PowerPoint file for the lectures on secondary and tertiary structure of proteins.
● 2c. The PowerPoint file for the hemoglobin lectures.
● 2d. The PowerPoint file for the sickle cell disease lecture.
● 2e. The PowerPoint file for the enzymology lectures.
● 2f. The lecture on Protease-Antiprotease Balance
● 2g. The figures for lectures 1-7
● 3. The figures for lectures 8-12
● 4. The figures for lectures 13-15
● 5. A homework problem and old exam questions.
● 6. Additional old exam questions.
● 7. A third old exam on proteins and enzymes.
● 8. The key to the 1998 exam on proteins and enzymes.
● 8a. The key to the 1999 exam on proteins and enzymes.
● 8b. The key to the 2000 exam on proteins and enzymes.
● 8c. The key to the 2001 exam on proteins and enzymes.
● 8d. The key to the 2002 exam on proteins and enzymes.
● 8e. A few salient points about protein structure.
● 8f. A few salient points about protein sequencing.
● 8g. A few salient points about enzyme kinetics.
● 9a. Dr. Schechter’s Objectives and Study Guide for Carbohydrate Metabolism.
● 9b1. Dr. Schechter’s First Lecture on Carbohydrate Metabolism.
● 9b2. Dr. Schechter’s Second Lecture on Carbohydrate Metabolism.
● 9b3. Dr. Schechter’s Third Lecture on Carbohydrate Metabolism.
● 9b4. Dr. Schechter’s Fourth Lecture on Carbohydrate Metabolism.
● 9b5. Dr. Schechter’s Fifth Lecture on Carbohydrate Metabolism.
● 9b6. Dr. Schechter’s Sixth Lecture on Carbohydrate Metabolism.
● 9b7. Dr. Schechter’s Seventh Lecture on Carbohydrate Metabolism.
● 9b8. Dr. Schechter’s Eighth Lecture on Carbohydrate Metabolism.
● 9c. The reading assignments, homework problems, and figures for the 2002 Metabolism lectures.
● 9d. Aaron Neiman’s 2003 Powerpoint Slides for Lectures 1 & 2 - Integration of Metabolism.
● 9e. Aaron Neiman’s 2003 Powerpoint Slides for Lectures 3 & 4 - Fatty Acid Catabolism.
● 9f. Aaron Neiman’s 2003 Powerpoint Slides for Lecture 5 - Fatty Acid Synthesis.
● 9g. Aaron Neiman’s 2003 Powerpoint Slides for Lecture 6 - Membrane Lipids.
● 9h. Aaron Neiman’s 2003 Powerpoint Slides for Lecture 7 - Amino Acid Synthesis.
● 9i. Aaron Neiman’s 2003 Powerpoint Slides for Lecture 8 - Amino Acid Catabolism - I.
● 9j. Aaron Neiman’s 2003 Powerpoint Slides for Lecture 9 - Amino Acid Catabolism - II.
● 9k. Aaron Neiman’s 2003 Powerpoint Slides for Lectures 10 & 11 - Purines and Pyrimidines.
● 9m. A “QuickTime” movie on Complex 1 (cf.9g).
● 9n. A “QuickTime” movie on Complex II (cf. 9g).
● 9o. A “QuickTime” movie on Complex III (cf. 9g).
● 9p. A “QuickTime” movie on Complex IV (cf. 9g).
● 10. Two old Metabolism Exams.
● 11. The key to the 1998 Metabolism Exam.
● 11a. The key to the 1999 Metabolism Exam.
● 11b. The key to the 1997 Metabolism Exam.
● 11c. The 2000 Metabolism Exam.
● 11d. The key to the 2000 Metabolism Exam.
● 11e. The 2001 Metabolism Exam.
● 11f. The key to the 2001 Metabolism Exam.
● 11g. Material from Dr. Lennarz on Cholesterol
● 11h. Dr. David Williams’ Lecture on Lipids and Lipoproteins.
● 11i. Dr. Henry Ginsberg’s Lecture on Lipids and Diabetes.
● 11j. The 2002 Metabolism Exam.
● 11k. The key to the 2002 Metabolism Exam.
● 12a. Corticosteroids and the Adrenals
● 12b. Bile Acids and Enterohepatic Circulation
● 12c. Porphyrias
● 12d. Bilirubin and Jaundice
● 13a. Nucleic Acids - DNA Replication
● 13b. Nucleic Acids - DNA Repair
● 13c. Nucleic Acids - Chromatin
● 13d. Nucleic Acids - Telomeres
● 13e. Nucleic Acids - RNA (Jen-Chih Hsieh)
● 13f. Nucleic Acids - Transcription & Development (Jen-Chih Hsieh)
● 13g. Nucleic Acids - Transcriptional Controls (Jen-Chih Hsieh)
● 13h. Protein Synthesis - Translation (Aaron Neiman)
● 13i. Protein Synthesis - Transport and Targeting (Aaron Neiman)
● 13j. Protein Degradation and Ubiquitin (Nisson Schechter)
● 13k. Genomics (Aaron Neiman)
● 13l. Nucleic Acids - homework problems
● 14. Nucleic Acids - more homework problems for exam preparation
● 15. Nucleic Acids - key to homework problems for exam preparation
● 16. Nucleic Acids - the 1996 and 1997 exams
● 17. Nucleic Acids - the key to the 1998 exam
● 17a. Nucleic Acids - the 1999 exam with key
● 17b. Nucleic Acids AND Medical Biochemistry - the 2000 exam
● 17b. Nucleic Acids AND Medical Biochemistry - the 2001 exam
● 18. Genetics - material from Drs. Freundlich and Katz
● 19a. Genetics 2001 - Dr. Marcu’s “Blackboard” slides in .PDF Format
● 19b. Dr. Marcu’s slides for 2002 in PowerPoint - Intro
● 19c. Dr. Marcu’s slides for 2002 in PowerPoint - First twenty
● 19d. Dr. Marcu’s slides for 2002 in PowerPoint - Last Nineteen
● 19e. Dr. Marcu’s Lecture for 2002 - Outline
● 19f. Dr. Marcu’s Old Exam Questions (practice)
● 19g. Dr. George Sack’s lecture on Glycogen Storage Diseases (PowerPoint)
● 19f. Dr. Nisson Schechter’s lecture on Ubiquitin and Protein Degradation (PowerPoint)
● 20. Genetics - material from Dr. Moll
● 21. Genetics - material from Dr. Carlson
● 22. Genetics - Dr. Parton’s 2003 Lecture Slides - Part I
● 22a. Genetics - Dr. Parton’s 2003 Lecture Slides - Part II
● 22b. Genetics - Dr. Parton’s 2003 Lecture Slides - Part III
● 22c. Genetics - Dr. Parton’s 2003 Lecture Slides - Part IV
● 22d. Genetics - Dr. Parton’s 2003 Lecture Slides - Part V
● 22e. Genetics - Dr. Parton’s 2003 Lecture Slides - Part VI
● 22f. Genetics - Dr. Parton’s 2003 Lecture Slides - Part VII
● 22g. Genetics - Homework problems for exam preparation (valuable practice)
● 22h. Genetics - Dr. Parton’s Practice Exam Questions (valuable practice)
● 22i. Genetics - Dr. Parton’s Practice Exam Questions - Key (valuable practice)
● 23. The 2002 Genetics Exam (with corrected answers)
● 23a. The 2000 Genetics Exam (with corrected answers)
● 24. The 1997 Genetics Exam
● 24a. The 1996 Genetics Exam
● 25. The 1995 Genetics Exam
● 26. The 1994 Genetics Exam
● 27. List of Inherited Disorders
● 28a. Membranes And Signal Transduction - material from Dr. McLaughlin for 2003 (includes outline and objectives for lectures I, II, and V of this series, reading guide, homework problems & study questions)
● 28b. Membranes - figures and notes for Dr. McLaughlin’s first two lectures (I,II) - 2003(includes additional problems & study questions)
● 28c. Membranes - figures and notes for Dr. McLaughlin’s third lecture (V) - 2003 (includes additional problems & study questions)
● 28d. Signal Transduction - material for Dr. T. Miller’s first Lecture, 2003
● 28e. Signal Transduction - slides for Dr. T. Miller’s first Lecture, 2003
● 28f. Signal Transduction - material for Dr. T. Miller’s second Lecture, 2003
● 28g. Signal Transduction - slides for Dr. T. Miller’s second Lecture, 2003
● 28h. Cell Signaling - Diagrams from Dr. Bar-Sagi, 2003 - Part I
● 28i. Cell Signaling - Diagrams from Dr. Bar-Sagi, 2002 - Part II
● 28j. Cell Signaling - Diagrams from Dr. Bar-Sagi from Previous Years
● 28k. Cell Signaling - Diagrams from Dr. Todd Miller from Previous Years
● 30a-d. Figures from Dr. Furie's Lecture: Set 1 ; Set 2 ; Set 3 ; Set 4
You should be receiving your TA assignments by e-mail - please transmit all homework problems to your TA.
To contact Dr. Simon: Office - BST-9 Room 151; phone - 631-444-3007; FAX - 631-444-7507; beeper - 631-733-8707