Michael Silverberg

Associate Professor of Medicine Emeritus

State University of New York at Stony Brook

Home Address:

6202 Karyn's Dead End Road
Efland, North Carolina, 27243-9291

Electronic Mail: michael.silverberg@stonybrook.edu

• Enzyme Kinetics and Chemistry
• Erythrocyte Membrane Glycoproteins (Glycophorin)
• Human Plasma Proteases (Contact Activation Pathway)

• Computer Literacy: School of Medicine
• Evidence Based Medicine: School of Medicine
• Classes for Faculty, Resident and Staff Development:
  • Bibliographic Databases
  • Scientific Graphing
  • Desktop Publishing
  • Electronic Mail
• Management of all on-line examinations for the School of Medicine

United University Professions:

Statewide:

Executive Board Member;
Four-time member of Statewide Negotiations Team;
Joint Labor Management Committee on Health Benefits.

Stony Brook Health Sciences Center Chapter: Vice President for Academics

1. Silverberg, M. and Dalziel, K. (l973); Crystalline 6-phosphogluconate Dehydrogenase from sheep liver. Eur. J. Biochem. 38:229-238.
2. Silverberg, M., Dalziel, K. and Adams, M.J. (1973); Crystalline phosphogluconate dehydrogenase from sheep liver. Biochem. Soc. Trans. 1: 1132-1134.
3. Silverberg, M. and Dalziel, K. (1975); 6-Phospho-D-Gluconate Dehydrogenase from sheep liver. Methods in Enzymology 41:214-220.
4. Silverberg, M. and Dalziel, K. (1975); Fluorescence studies of coenzyme binding to 6-phosphogluconate dehydrogenase. Arch. Biochem. Biophys. 68:646-651.
5. Silverberg, M., Furthmayr, H. and Marchesi, V.T. (1976); The effect of carboxymethylating a single methionine residue on the subunit interactions of glycophorin A. Biochemistry, 15:1448-1454.
6. Silverberg, M., Chow, C.C. and Marchesi, V.T. (1977); Oxidation of methionine causes a change in the electrophoretic mobility of the major sialoglycoprotein of the human erythrocyte membrane. Biochem. Biophys. Acta. 494:441-445.
7. Marchesi, V.T., Furthmayr, H., Tomita, M., Silverberg, M. and Cotmore, S. (1977); Molecular features of glycophorin A. The major sialoglycoprotein of the human red cell membrane. In "Human Blood Groups", (Eds: Mohn et al) Karger, N.Y.{Proceedings of the 5th Int. Conf. on Immunology].
8. Silverberg, M. and Marchesi, V.T. (1978); Anomalous electrophoretic behaviour of the major sialoglycoprotein of the human erythrocyte membrane. J. Biol. Chem. 253:95-98.
9. Sealey, J.E., Atlas, S.A., Laragh, J.H., Silverberg, M. and Kaplan, A.P. (1979); Initiation of plasma prorenin activation by Hageman factor- dependent conversion of plasma prekallikrein to kallikrein. Proc. Natl. Acad Sci. 767:5914-5918.
10. Sealy, J.E., Atlas, S.A., Laragh, J.H., Silverberg, M. and Kaplan, A.P. (1979); Plasmin can activate plasma prorenin but is not required for the alkaline phase of acid activation. Clin. Sci. 57:97s-99s.
11. Miller, G., Silverberg, M. and Kaplan, A.P. (1980); Autoactivatability of human Hageman factor (Factor XII). Biochem. Biophys. Res. Commun. 92:803- 810.
12. Silverberg, M., Thompson, R., Miller, G. and Kaplan, A.P. (1980); Initiation of the intrinsic coagulation pathway: Autoactivatability of human Hageman factor and the mechanisms by which the light chain derived from HMW-kininogen functions as a cofactor in the activation of prekallikrein, factor XI and Hageman factor. In "The Regulation of Coagulation". (Eds: Mann & Tayler) Elsevier North Holland, Inc.
13. Silverberg, M., Dunn, J.T., Garen, L. and Kaplan, A.P. (1980); Autoactivation of human Hageman factor: Demonstration utilizing a synthetic substrate. J. Biol. Chem. 255:7281-7286.
14. Silverberg, M., Nicoll, J.E. and Kaplan, A.P. (1980); The mechanism by which the light chain of cleaved HMW-kininogen augments the activation of prekallikrein, factor XI, and Hageman factor. Thromb. Res. 20:173-189.
15. Kaplan, A.P., Silverberg, M., Dunn, J.T. and Miller, G. (1981); Mechanisms for Hageman factor activation and the role of HMW-kininogen as a coagulation cofactor. Annals. N.Y. Acad. Sci. 370:253-260.
16. Kaplan, A.P., Ghebrehiwet, B., Silverberg, M., and Sealey, J. (1981); The intrinsic coagulation-kinin pathway, complement cascades, plasma renin- angiotensin system and their interrelationships. In "CRC Critical Reviews in Immunology", (ed. M.Z. Atassi) CRC Press, Boca Raton, Fl.
17. Ghebrehiwet, B., Silverberg, M. and Kaplan, A.P. (1981); Activation of the classical pathway of complement by Hageman factor fragment. J. Exp. Med. 153:665-676.
18. Silverberg, M. and Kaplan, A.P. (1981); The activation of Hageman factor. Advances in Inflammation Research. Vol. 2, 165-185. Ed. G. Weissman. Raven Press. N.Y.
19. Silverberg, M. and Kaplan, A.P. (1982); Deficiency of Factor XI. In "Hemostasis and Thrombosis" (Colman et al, Eds). J.B. Lippincott Co.
20. Dunn, J.T., Silverberg, M. and Kaplan, A.P. (1982); the cleavage and formation of activated human Hageman factor by autodigestion and by kallikrein. J. Biol. Chem. 257:1779-1784.
21. Silverberg, M. and Kaplan, A.P. (1982); Enzymatic activities of activated and zymogen forms of human Hageman factor (Factor XII). Blood 60:64-70.
22. Silverberg, M. (1983); Assay of coagulation factors using synthetic chromogenic substrates. In "Methods in Hematology". Churchill Livingstone. 7:1-23.
23. Ghebrehiwet, B., Randazzo, B.P., Dunn, J.T., Silverberg, M. and Kaplan, A.P. (1983); Mechanisms of activation of the classical pathway of complement by Hageman factor fragment. J. Clin. Invest. 71:1450-1456.
24. Silverberg, M. and Dunn, J.T. (1983); The effect of surfactants on the interaction of Factor XII with surfaces. Thromb. Res. 31:255-260.
25. Kaplan, A.P., Silverberg, M. and Ghebrehiwet, B. (1984); Initiation of plasma proteolytic cascades: The intrinsic coagulation/kinin pathway, the classical complement pathway and their interaction. Proceedings of International Kinin Congress, 1984. In press.
26. Silverberg, M. (1985); The contact activation/kinin system in man. In "Allergy". A.P. Kaplan, Ed. Churchill Livingstone, New York, N.Y.
27. Messina, M.S., Perry, R., Silverberg, M., Kaplan, A.P. and Smaldone, G.C. (1985); Quantitative assays of pharmacologic aerosols used in studying asthma. J. Allergy Clin. Immunol. 76:605-609.
28. Becker, C. G., Wagner, M., Kaplan, A. P., Silverberg, M., Grady, R. W., Liem, H. and Muller-Eberhard, U. (1985); Activation of Factor XII dependent pathways in human plasma by hematin and protoporphyrin. J. Clin. Invest. 76:413-419
29. Meier, H. L., Flowers, B., Silverberg, M., Kaplan, A. P. and Newball, H. H. (1986) The IgE dependent release of a Hageman factor cleaving factor from human lung. Am.J.Pathol. 123:146-154.
30. Weiss, R., Silverberg, M. and Kaplan, A. P. (1986) The effect of C1 Inhibitor upon Hageman factor autoactivation. Blood 68:239-243.
31. Silverberg, M., Longo, J., and Kaplan, A.P. (1986). Study of the effect of high molecular weight kininogen upon the fluid phase inactivation of kallikrein by C1 INH. J. Biol. Chem. 261:14965-14968.
32. Kaplan, A.P. Sheikh, I. and Silverberg, M. (1986); Bradykinin: Mechanism of formation and role in allergic disorders. Proceedings of the XII International Congress of Allergology and Clinical Immunology. (Reed, Ed.) pp. 278-284
33. Kaplan, A.P. and Silverberg, M. (1987) The coagulation-kinin pathway of human plasma. Blood 70:1-15.
34. Silverberg, M. and Diehl, S. (1987). The autoactivation of human factor XII induced by heparin and low molecular weight dextran sulfate. Biochem. J. 248:715-720.
35. Silverberg, M. and Diehl, S.V. (1987) The activation of the contact system of human plasma by polysaccharide sulfates. Ann N.Y. Acad Sci. 516:268-279.
36. Kaplan, A.P. and Silverberg, M.(1988) Methods in Enzymology. vol 163. -3 chapters: a) Mediators of Inflammation, b) Hageman factor, c) Prekallikrein .
37. Silverberg, M. and Kaplan, A.P. (1988) The effects of Neurotropin upon the Kallikrein -Kinin System
38. Silverberg, M. (1989) Hageman Factor Activation by Poly saccharides: Effect of molecular weight. Advances in Experimental Medicine and Biology, Vol 247A pp.453-460 (Proceedings of the Fifth International Kinin Conference)
39. Cheri L. Cameron, Beate Fisslthaler, Andrew Sherman, Sesha Reddigari and Michael Silverberg. (1989) Studies of contact activation: Effects of surface and inhibitors. Medical Progress through Technology. 15:53-62
40. Kaplan, A. P., M. Silverberg, B. Ghebrehiwet, P. Atkins and B. Zweiman (1989). "Pathways of kinin formation and role in allergic diseases. ." Clin Immunol Immunopathol 50 : S41-51 .
41. Nishikawa, K., Reddigari, S.R., Silverberg, M., Kuna, P.B., Yago, H., Nagaki, Y., Toyomakii, Y., Suehiro, S., Kaplan, A.P. (1992) Effect of Neurotropin on the activation of the plasma kallikrein-kinin system. Biochem. Pharm. 43:1361-1369.
42. Silverberg, M: Prekallikrein. In: Human Protein Data . (Ed.) A. Haeberli VCH, Weinheim. (1992)
43. Brunnée, T., G. Coy, S. R. Reddigari and M. Silverberg (1992). "Factors Affecting the Rate of Contact Activation in Human Plasma." AAS 38/II: 231-236.
44. Kaplan, A. P., S. Reddigari, T. Brunnée, K. Nishikawa, P. Kuna and M. Silverberg (1992). "Studies of the activation and inhibition of the plasma kallikrein-kinin system. [Review]." Agents & Actions Supplements :
45. Kaplan, A.P., Reddigari, S. and Silverberg. M. (1992) Assessment of the plasma kinin-forming pathways in allergic diseases. in "The Kallikrein-Kinin System in Health and Disease" (H. Fritz, I Schmidt and G. Dietz, eds)
46. Brunnée, T., LaPorta, C.,Reddigari, S.,Salerno, V.M., Kaplan, A.P. and Silverberg, M. (1993) Activation of factor XI in plasma is dependent on factor XII. Blood, 81:580-586.
47. Schulman, M., Hakim, R., Anias, R., Silverberg, M. Kaplan, A.P. and Arbeit, L. (1993) Bradykinin generation by dialysis membranes: possible role in anaphylactic reaction. J.Am.Soc. Nephrol. 3:1563-1568.
48. Michael Silverberg, Sesha Reddigari, Allen P. Kaplan. The Contact System and its Disorders. Chapter in ³Blood: Principles and Practice of Hematology² (Handin, Lux & Stossel, EDs) J. B. Lippincott, Philadelphia.1995
49. Brunnée, T. Reddigari, S.R., Shibayama, Y., Kaplan, A.P. (1997) Mast Cell derived Heparin activates the contact system: a link to kinin generation in allergic reactions. Clinical and Experimental Allergy, 27:653-663
50. Gibson, K.E. and Silverberg. M. (1999) A two year experience teaching computer literacy to first year medical students. Bull Med Libr Assoc 2000 Apr;88(2):157-64.